X-ray structural studies of chiral β-lactam formation from an achiral oxo amide using the chiral-crystal environment

Article abstract of DOI:10.1021/ja00184a045

Chiral crystals of the achiral oxo amide 1, prepared in large quantities, were irradiated in the solid state to give the optically active β-lactam 2 in high optical and chemical yields. The asymmetric induction mechanism has been elucidated by X-ray struc