Facile synthesis of trifluoromethyl carbinols and trifluoromethyl- α,β-unsaturated ketones from the new CF3CHO synthetic equivalent, 1,1- bis(dimethylamino)-2,2,2-trifluoroethane

Article abstract of DOI:10.1016/S0040-4039(98)02106-6

1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCl catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbino