A practical synthesis of 4′-methylbiphenyl-2-carbonitrile as a key intermediate of angiotensin II antagonists

Article abstract of DOI:10.1080/00397919608004788

A new and practical synthesis of 4′-methylbiphenyl-2-carbonitrile, a key intermediate of angiotensin II antagonists is described. The key step is Pd-catalyzed dehydrogenation of the compound 6, which proceeds selectively by utilizing hydrogen acceptor such as maleic diester or oxygen.

Full text of DOI:10.1080/00397919608004788

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Synthetic Communications: An
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A Practical Synthesis of 4′-
Methylbiphenyl-2-carbonitrile
as a Key Intermediate of
Angiotensin II Antagonists
Yumiki Noda a , Yoshikazu Akiba a & Mikito Kashima a
a Corporate Research and Development , UBE
Industries, LTD. , 1978–5, Kogushi Ube-city,
Yamaguchi, 755, Japan
Published online: 21 Aug 2006.
To cite this article: Yumiki Noda , Yoshikazu Akiba & Mikito Kashima (1996) A
Practical Synthesis of 4′-Methylbiphenyl-2-carbonitrile as a Key Intermediate of
Angiotensin II Antagonists, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 26:24, 4633-4639, DOI:
10.1080/00397919608004788
To link to this article: http://dx.doi.org/10.1080/00397919608004788
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