Acyclic Stereoselection. 8. A New Class of Reagents for the Highly Stereoselective Preparation of threo-2-Alkyl-3-hydroxycarboxylic Acids by the Aldol Condensation

DOI: 10.1021/jo01297a057

Source and publish data:

Journal of Organic Chemistry p. 1727 - 1728 (1980)

Update date:2022-08-17

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Authors:

Pirrung, Michael C.

Heathcock, Clayton H.

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Article abstract of DOI:10.1021/jo01297a057

threo-3-Hydroxy-2-methylcarboxylic acids may be prepared in high stereochemical yield by condensing aryl propionates 1 or 2 with aldehydes followed by hydrolytic or oxidative removal of the aryl group.

Full text of DOI:10.1021/jo01297a057

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