A new facile preparation of a bifunctionalized C6 homologating agent from 1,4-cyclohexadiene

Article abstract of DOI:10.1016/S0040-4020(99)00077-0

a new preparation of the bifunctionalized unsaturated C6 homologating agent 2b which is an efficient synthetic tool is described. This method is atom economic, very efficient on grams scale and easy to handle from cheap commercially available 1,4-cyclohexadiene. Synthetic applications by using a mild and selective monohydrolysis of acetal catalyzed by FeCl₃ are described.