Tetrahedron Letters p. 3015 - 3018 (1984)
Update date:2022-08-11
Topics:
Norman, G. David
Reese, B. Colin
Serafinowska, T. Halina
The suitability of the 4-methoxytetrahydropyran-4-yl group for the protection of 2' ( or 3')-hydroxy functions in oligoribonucleotide synthesis is confirmed; the latter protecting group is removed in 0.01M-hydrochloric acid at room temperature under conditions which, contrary to a recent report, lead to no detectable cleavage or migration of the internucleotide phosphodiester linkages.
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(1972)
