THE PROTECTION OF 2'-HYDROXY FUNCTIONS IN OLIGORIBONUCLEOTIDE SYNTHESIS

DOI: 10.1016/S0040-4039(01)81352-6

Source and publish data:

Tetrahedron Letters p. 3015 - 3018 (1984)

Update date:2022-08-11

Topics:

Authors:

Norman, G. David

Reese, B. Colin

Serafinowska, T. Halina

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Article abstract of DOI:10.1016/S0040-4039(01)81352-6

The suitability of the 4-methoxytetrahydropyran-4-yl group for the protection of 2' ( or 3')-hydroxy functions in oligoribonucleotide synthesis is confirmed; the latter protecting group is removed in 0.01M-hydrochloric acid at room temperature under conditions which, contrary to a recent report, lead to no detectable cleavage or migration of the internucleotide phosphodiester linkages.

Full text of DOI:10.1016/S0040-4039(01)81352-6

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