Archiv der Pharmazie p. 640 - 644 (1995)
Update date:2022-07-30
Topics:
Medarde
Pelaez-Lamamie De Clairac
Luis Lopez
Gravalos
San Feliciano
Several chloro- and iodo-lignanolides have been obtained by direct halogenation of aromatic rings from yatein and 4'-O-demethylyatein. They were assayed as antineoplastics, in order to check the influence in the activity of substitution in both aromatic rings. Although these compounds show a modest antineoplastic activity, it is far from that displayed by yatein and podophyllotoxin. These results confirm that demethylation and the introduction of halo substituents diminish the activity of lignans of the dibenzylbutyrolactone type.
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Doi:10.1016/0008-6215(88)84022-9
(1988)Doi:10.1021/jm100593s
(2010)Doi:10.1021/om960184j
(1996)Doi:10.1055/s-0029-1217814
(2009)Doi:10.1016/j.tetlet.2009.08.061
(2009)Doi:10.1016/j.tetlet.2009.08.062
(2009)
