Synthesis and mass spectrometry analysis of oligonucleotides bearing 5- formyl-2'-deoxyuridine in their structure

Article abstract of DOI:10.1080/07328319608002430

Two oligonucleotides containing FdU (1) have been synthesized. The use of the 'Pac-amidites' for the natural nucleosides has allowed the incorporation of the oxidized thymine residue without protection of the aldehydic function. The oligonucleotide composition was confirmed by enzymatic digestion and electrospray mass spectrometry.

Full text of DOI:10.1080/07328319608002430

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Synthesis and Mass Spectrometry
Analysis of Oligonucleotides Bearing
5-Formyl-2′-Deoxyurldlne in Their
Structure
T. Berthod a , Y. Pétillot b , A. Guy a , J. Cadet a , E. Forest b & D.
Molkot a
a Département de Recherche Fondamentale sur la Matière
condensée /S. C. I. B./ Lésions des Acides Nucléiques , CEA /
Grenoble, 17, Rue des Martyrs, 38054, Grenoble, Cedex 9, France
b Laboratoire de Spectrométrie de Masse des Protéines , lnstitut
de Biologie Structurale (CEA/CNRS) , 41 Rue des Martyrs, 38027,
Grenoble, Cedex 1, France
Published online: 22 Aug 2006.
To cite this article: T. Berthod , Y. Pétillot , A. Guy , J. Cadet , E. Forest & D. Molkot (1996) Synthesis
and Mass Spectrometry Analysis of Oligonucleotides Bearing 5-Formyl-2′-Deoxyurldlne in Their
Structure, Nucleosides and Nucleotides, 15:7-8, 1287-1305, DOI: 10.1080/07328319608002430
To link to this article: http://dx.doi.org/10.1080/07328319608002430
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