The dolastatins. 21. Synthesis, X-ray crystal structure, and molecular modeling of (6R)-isodolastatin 10

DOI: 10.1021/jo00100a001

Source and publish data:

Journal of Organic Chemistry p. 6127 - 6130 (1994)

Update date:2022-08-16

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Authors:

Pettit Pettit

Srirangam

Herald Herald

Hamel Hamel

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Article abstract of DOI:10.1021/jo00100a001

A practical synthesis of (6R)-isodolastatin 10 (1b) was devised, the X-ray crystal structure was determined, and this chiral isomer was found to have antineoplastic activity comparable to dolastatin 10 (1a).

Full text of DOI:10.1021/jo00100a001

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