An improved method for chiral oxazaborolidine-catalyzed reduction of 4- chromanone analogs and MK-0499

DOI: 10.1016/S0040-4039(00)78232-3

Source and publish data:

Tetrahedron Letters p. 6409 - 6412 (1994)

Update date:2022-08-17

Topics:

Authors:

Shi Shi

Cai Cai

Dolling Dolling

Douglas Douglas

Tschaen Tschaen

Verhoeven

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Article abstract of DOI:10.1016/S0040-4039(00)78232-3

Addition of isopropanol to the stoichiometric reduction of ketones 4 - 8 using oxazaborolidine-borane complex 3 or the oxazaborolidine-catalyzed reduction of 4-chromanone analogs (1, 7 - 9) enhances the enantioselectivity of the reduction.

Full text of DOI:10.1016/S0040-4039(00)78232-3

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