Synthesis of a cumyl analogue in nitrothiazole series and S(RN)1 reaction at tertiary carbon

Article abstract of DOI:10.1016/S0040-4039(97)00243-8

A new alkylating agent, 2-(1-methyl-1-nitroethyl)-5-nitrothiazole, bearing a tertiary nitro nucleofuge, reacts with 2-nitropropane anion by S(RN)1 mechanism leading to the C-alkylation product.