Oxidative cleavage of aryl oxazolines using Methyl(trifluoromethyI)dioxirane generated in situ

Article abstract of DOI:10.1016/S0040-4039(97)01654-7

Oxidative cleavage of aryl oxazoline 2 using methyl(trifluoromethyl)dioxirane la generated in situ provides the intermediate nitro-ester 8, which undergoes a basic hydrolysis to furnish benzoic acid 11. Even the hindered oxazoline 7 can be cleaved smoothly to afford 3,3'-dimethyl-2,2'-diphenic acid 16. All substituted benzoic acids 11-16 can be isolated in excellent yields (80-95 %).