The synthesis of novel analogues of the manumycin family of antibiotics and the antitumour antibiotic LL-C10037α

Article abstract of DOI:10.1016/0040-4039(96)00203-1

Efficient approaches to the central amino-epoxycyclohexenone core of the manumycin family of antibiotics are described. The use of this methodology to prepare the antitumour antibiotic LL-C10037α and its epimer, both in racemic form, and a number of analogues of manumycin, alisamycin and asukamycin, lacking the C-4 substituent, are then outlined.