" Mediator Methodology" for the Synthesis of Peptides in a Two-Polymeric System

Article abstract of DOI:10.1021/ja00300a029

Abstract: A novel methodology is described for a potential automated self-controlled synthesis of peptides.The method is based on transferring an N-protected amino acid from one insoluble polymer (donor) such as a polymeric o-nitrophenyl ester (a "bank" of active ester) to an insoluble polymer-bound amino acid (acceptor),with the aid of a soluble mediator molecule (shadchan)² The method gives high yields of pure peptides by garanteeing stoichiomeric supply of the active ester and allowing self monitoring.When the polymer-bound (dimethylamino)pyridinium salts, the condensation reaction was expended to also include sulfonation and particularly phosphorylation reactions.