Bioorganic and Medicinal Chemistry Letters p. 1377 - 1380 (1997)
Update date:2022-08-12
Topics:
Wright, Jon L.
Gregory, Tracy F.
Heffher, Thomas G.
MacKenzie, Robert G.
Pugsley, Thomas A.
Vander Meulen, Seth
Wise, Lawrence D.
High volume screening identified 3-(4-benzylpiperidinyl)- 1-naphthoxy-2-propanol as a selective dopamine D4 receptor ligand. A systematic structure-activity study revealed that the benzyl group could be replaced with phenoxy and the naphthalene with phenyl to improve potency almost tenfold. The (R) enantiomer of this compound had a D4 affinity of 2 nM and was over 100-fold weaker at dopamine D2 and D3 receptors.
View MoreBeyond Pharmaceutical Co., Ltd
Contact:+86-571-8195-3185
Address:No. 13-1, Liansheng Road, Yuhang District
Chengdu Chengnuo New-Tech Co., Ltd
Contact:0086-028-85749078
Address:4 Jiuyang road,Jiulong industrial port,Chengdu, China
ZhangJiaGang YaRui Chemical Co.,Ltd.
Contact:0512-58360968
Address:China JiangSu Province Zhang Jia Gang City YangShe Oriental Plaza Building 10 B307
Contact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Contact:+86-13666670345
Address:Agricultural Development Zone, Haining, Jiaxing, Zhejiang
Doi:10.1021/acs.joc.7b00180
(2017)Doi:10.1124/jpet.106.114322
(2007)Doi:10.1039/c1ob05115f
(2011)Doi:10.1139/v64-369
(1964)Doi:10.1021/ja01558a016
()Doi:10.1021/ol8022227
(2008)