Mass spectrometry of ring D hydroxylated 3-methoxy-1,3,5(10)-estratrienes

Article abstract of DOI:10.1016/0039-128X(80)90077-X

Mass spectra and fragmentation patterns of the epimeric 17-,16-,15- and 14-hydroxy derivatives of 3-methoxy- 1,3,5(10)-estratriene are compared. The main fragmentation pathways are differently influenced, depending on the position of the hydroxy group. The different configuration of the hydroxy groups is reflected only in the spectra of the epimeric 15- and 14-hydroxy compounds. Possibilities of mass spectrometric differentiation between the hydroxy-estratrienes are discussed.