Bioorganic and Medicinal Chemistry Letters p. 1221 - 1226 (1996)
Update date:2022-08-11
Topics:
Zimmermann, Juerg
Buchdunger, Elisabeth
Mett, Helmut
Meyer, Thomas
Lydon, Nicholas B.
Traxler, Peter
Phenylamino-pyrimidines represent a novel class of inhibitors of the PDGF-receptor autophosphorylation with a high degree of selectivity versus other tyrosine and serine/threonine kinases. Optimum activity of ca 10 nM (IC50) was observed when the phenylamino-group which is attached to the pyrimidine carries a benzamide-moiety with a lipophilic substituent in 4-position. Copyright
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