Organic Letters
Letter
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unactivated arenes with haloarenes in the presence of
potassium tert-butoxide. Good to excellent yields can be
obtained for a wide range of aryl iodides. One significant and
advantageous feature of this new catalytic system lies in its low
catalyst loading of 5 mol %, especially in comparison with the
catalyst loadings of 10 to 40 mol % required for all
organocatalyts developed by others for the same type of
arylation reactions.1 We believe this simple easily accessible
organocatalyst might find interesting uses in constructing
pharmaceutically important biaryl scaffolds.
ASSOCIATED CONTENT
* Supporting Information
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S
The Supporting Information is available free of charge on the
Synthetic procedures and characterizations (1H and 13C
NMR) for arylation products (PDF)
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Ferrand, Y.; Bao, C.; Kauffmann, B.; Grelard, A.; Jiang, H.; Huc, I.
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AUTHOR INFORMATION
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Corresponding Author
ORCID
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
This work was supported by the Institute of Bioengineering and
Nanotechnology (Biomedical Research Council, Agency for
Science, Technology and Research, Singapore) and Shandong
Provincial Natural Science Foundation, China (ZR2016JL009).
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