Cyclization of N-allylthiourea derivatives by the action of α-chloronitrosoalkanes

Article abstract of DOI:10.1007/BF02290730

A convenient method is proposed for obtaining difficultly available derivatives of 2-amino-5-chloromethyl-2-thiazoline by the cyclization of N-allylthioureas under the action of α-chloronitrosoalkanes. It is assumed that the reaction proceeds as a halogenophilic process leading to the intermediate formamidinesulfenyl chloride which is rapidly and selectively cyclized with the formation of 2-amino-2-thiazoline derivatives. 1998 Plenum Publishing Corporation.