An efficient asymmetric hydrogenation approach to the synthesis of the Crixivan piperazine intermediate

Article abstract of DOI:10.1016/S0040-4039(98)01484-1

The Crixivan HIV protease inhibitor piperazine intermediate 2 was prepared by a four step sequence using a chiral hydrogenation of the tetrahydropyrazine 9 to establish the absolute stereochemistry.