Carbonylation of 2-chloro-4,6-dimethoxypyrimidine and 2-(chloromethyl)- 4,6-dimethoxypyrimidine

Article abstract of DOI:10.1016/S0040-4020(98)01038-2

The preparation of pyrimidine-2-carboxylates and 2-pyrimidineacetates by alkoxycarbonylation of respectively 2-chloropyrimidine and 2- (chloromethyl)pyrimidine with carbon monoxide in the presence of palladium acetate and 1,1'-bis(diphenylphosphino)ferroc