From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H3-receptor antagonists

DOI: 10.1016/S0960-894X(99)00272-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1825 - 1830 (1999)

Update date:2022-08-11

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Authors:

Tozer, Matthew J.

Harper, Elaine A.

Kalindjian, S. Barret

Pether, Michael J.

Shankley, Nigel P.

Watt, Gillian F.

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Article abstract of DOI:10.1016/S0960-894X(99)00272-3

Histamine was converted to a selective histamine H₃-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher receptor affinity and lower variability in the data from the various bioassays were achieved with the 2-naphthalensulfonamides of histamine homologues.

Full text of DOI:10.1016/S0960-894X(99)00272-3

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