From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H3-receptor antagonists

Article abstract of DOI:10.1016/S0960-894X(99)00272-3

Histamine was converted to a selective histamine H₃-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher receptor affinity and lower variability in the data from the various bioassays were achieved with the 2-naphthalensulfonamides of histamine homologues.