Lanthanide Complexes with High Stability and Efficiency for the Hydrolysis of a Ribonucleotide Dimer

Article abstract of DOI:10.1246/cl.1995.665

Lanthanide complexes with N,N,N'N'-tetrakis<(2-pyridyl)methyl>ethylenediamine (TPEN) efficiently hydrolyze a ribonucleotide dimer, ApA, at 35 deg C, pH = 7.2.The activity of La³⁺-TPEN is greater than of free La³⁺ ion.The Ln³⁺-TPEN complexes are sufficiently stable in neutral aqueous solutions (the formation constants are in the range log K/mol^-1dm³ = 3.9 - 6.2).These complexes are promising for the active site of artificial ribonucleases.