Acetyl chloride-methanol as a convenient reagent for: A) quantitative formation of amine hydrochlorides; B) carboxylate ester formation; C) mild removal of N-t-Boc-protective group

Article abstract of DOI:10.1080/00397919808005101

Hydrogen chloride quatitativaly generated in situ by the addition of acetyl chloride to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.

Full text of DOI:10.1080/00397919808005101

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Synthetic Communications: An
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Organic Chemistry
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Acetyl Chloride-Methanol as
a Convenient Reagent for:
A) Quantitative Formation
of Amine Hydrochlorides B)
Carboxylate Ester Formation
C) Mild Removal of N-t-Boc-
Protective Group.
Ayelet Nudelman a , Yosi Bechor a , Eliezer Falb
a , Bilha Fischer a , Barry A. Wexler b & Abraham
Nudelman a
a Department of Chemistry, Bar Ilan University,
Ramat Gan, 52900, Israel
b Dupont Agricultural Products, Stine-Haskell
Research Center, P. O. Box 30, Newark, DE,
19714-0030, USA
Available online: 15 Aug 2006
To cite this article: Ayelet Nudelman, Yosi Bechor, Eliezer Falb, Bilha Fischer, Barry
A. Wexler & Abraham Nudelman (1998): Acetyl Chloride-Methanol as a Convenient
Reagent for: A) Quantitative Formation of Amine Hydrochlorides B) Carboxylate Ester
Formation C) Mild Removal of N-t-Boc-Protective Group., Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
28:3, 471-474

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