Tetrahedron p. 943 - 954 (1999)
Update date:2022-08-11
Topics:
Maeda, Hiroshi
Selvakumar, Natesan
Kraus, George A.
A synthesis of 4-aryl kainic acid analogs was achieved using a highly stereoselective Michael addition reaction of dimethyl 2-oxoglutarate with a nitrostyrene. Nitro group reduction, deoxygenation and epimerization complete the synthetic route.
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