Rate enhancement with high ratio of the monoalkylated product to the dialkylated product in the alkylation of the lithium enolate of 1-tetralone with reactive alkyl halides

DOI: 10.1248/cpb.48.1529

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1529 - 1531 (2000)

Update date:2022-08-11

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Authors:

Goto Goto

Akimoto Akimoto

Aoki Aoki

Shindo Shindo

Koga Koga

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Article abstract of DOI:10.1248/cpb.48.1529

The reactions of the lithium enolate of 1-tetralone with reactive alkyl halides were examined in the absence and in the presence of 3 eq of various ligands for the lithium. It is shown that the rates of the reactions are enhanced greatly in the presence a tetradentate amine (1,1,4,7,10,10-hexamethyltriethylenetetramine), and the ratio of the monoalkylated product to the dialkylated product is increased under shorter reaction times.

Full text of DOI:10.1248/cpb.48.1529

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