Chemical and Pharmaceutical Bulletin p. 19 - 26 (1994)
Update date:2022-08-10
Topics:
Kobayashi
Kawazoe
Okamoto
Sasaki
Kitagawa
Acidic treatment of swinholide A (1), which was characterized as the major cytotoxic macrolide from the Okinawan marine sponge Theonella swinhoei, provided several isomeric macrolides having different size of the dilactone ring structure. From the structure-activity correlation viewpoint, the in vitro cytotoxicities and in vivo antitumor activities of these dimeric macrolides, together with two monomeric macrolides which were synthesized from 1, have been examined.
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Doi:10.1039/c39950000923
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