Substituted piperidines - Highly potent renin inhibitors due to induced fit adaptation of tile active site

Article abstract of DOI:10.1016/S0960-894X(99)00195-X

The identification, synthesis and activity of a novel class of piperidine renin inhibitors is presented. The most active compounds show activities in the picomolar range and are among the most potent renin inhibitors ever identified.