Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation

DOI: 10.1016/j.bmc.2018.02.040

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Bioorganic and Medicinal Chemistry p. 1939 - 1949 (2018)

Update date:2022-07-30

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Authors:

Zhou, Zhengyuan

Chitneni, Satish K

Devoogdt, Nick

Zalutsky, Michael R.

Vaidyanathan, Ganesan

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Article abstract of DOI:10.1016/j.bmc.2018.02.040

In a previous study, we evaluated a HER2-specific single domain antibody fragment (sdAb) 2Rs15d labeled with ¹⁸F via conjugation of a residualizing prosthetic agent that was synthesized by copper-catalyzed azide-alkyne cycloaddition (CuAAC). In

Full text of DOI:10.1016/j.bmc.2018.02.040

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