The 'β-fluorine effect' in the non-metal hydride radical deoxygenation of fluorine-containing nucleoside xanthates

Article abstract of DOI:10.1080/15257770008032993

An alternative method to conduct a Barton-McCombie deoxygenation in nucleosides is described. The utility of the procedure is limited to structures with an electronegative substituent, particularly fluorine, in the β-position relative to the radical cente

Full text of DOI:10.1080/15257770008032993

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Nucleosides, Nucleotides and Nucleic
Acids
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The “β-Fluorine Effect” in the Non-
Metal Hydride Radical Deoxygenation
of Fluorine-Containing Nucleoside
Xanthates
Maqbool A. Siddiqui a , John S. Driscoll a , Elie Abushanab a b , James
A. Kelley a , Joseph J. Barchi Jr. a & Victor E. Marquez a
a Laboratory of Medicinal Chemistry, Division of Basic Sciences,
National Cancer Institute, NIH , Bethesda, MD, 20892, U.S.A.
b The University of Rhode Island
Published online: 24 Sep 2006.
To cite this article: Maqbool A. Siddiqui , John S. Driscoll , Elie Abushanab , James A. Kelley , Joseph
J. Barchi Jr. & Victor E. Marquez (2000) The “β-Fluorine Effect” in the Non-Metal Hydride Radical
Deoxygenation of Fluorine-Containing Nucleoside Xanthates, Nucleosides, Nucleotides and Nucleic
Acids, 19:1-2, 1-12, DOI: 10.1080/15257770008032993
To link to this article: http://dx.doi.org/10.1080/15257770008032993
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