Asymmetric hydrogenation of 2-benzylidenesuccinic acid 4-[(4-BOC-amino)-1-piperidide] monoamide: Key step in a process for large scale preparation of a renin inhibitor

DOI: 10.1055/s-1994-25511

Source and publish data:

Synthesis p. 494 - 498 (1994)

Update date:2022-08-17

Topics:: Authors:

Jendralla

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Article abstract of DOI:10.1055/s-1994-25511

The N-terminal component 4 of an orally active renin inhibitor is prepared on kg-scale by asymmetric hydrogenation of the title compound 3. Enantioselectivities of several homogeneous homochiral rhodium(I)- and ruthenium(II)-diphosphine catalysts are compared.

Full text of DOI:10.1055/s-1994-25511

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Asymmetric hydrogenation of 2-benzylidenesuccinic acid 4-[(4-BOC-amino)-1-piperidide] monoamide: Key step in a process for large scale preparation of a renin inhibitor

DOI: 10.1055/s-1994-25511

Source and publish data:

Authors:

Article abstract of DOI:10.1055/s-1994-25511

Full text of DOI:10.1055/s-1994-25511

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