Simple phase transfer catalytic method for α-methoxylation of sterically hindered ketones

Article abstract of DOI:10.1080/00397919508013839

Reactions of sterically hindered ketones of ArylCOCHR¹R² type (R¹, R² = Me, Et, Ph) with carbon tetrachloride and methyl iodide in the presence of solid KOH and 18-crown-6 afford the corresponding α-methoxyketones [ArylCOC(OMe)R¹R²] in one-pot process in 30-67% yields.

Full text of DOI:10.1080/00397919508013839

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Synthetic Communications: An
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Organic Chemistry
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Simple Phase Transfer Catalytic
Method for α-Methoxylation of
Sterically Hindered Ketones
E. Abele a , K. Rubina a , M. Shymanska a & E.
Lukevics a
a Latvian Institute of Organic Synthesis, Aizkraukles,
21, Riga, LV-1006, Latvia
Published online: 23 Sep 2006.
To cite this article: E. Abele , K. Rubina , M. Shymanska & E. Lukevics (1995): Simple
Phase Transfer Catalytic Method for α-Methoxylation of Sterically Hindered Ketones,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 25:9, 1371-1376
To link to this article: http://dx.doi.org/10.1080/00397919508013839
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