Structures of puwainaphycins A-E

Article abstract of DOI:10.1016/S0040-4020(01)92264-1

Puwainaphycins A-E, one of which (C) is a potent cardioactive agent in isolated mouse atria, are cyclic decapeptides that have beeen isolated from a terrestrial blue-green alga Annabaena sp. BQ-16-1. The structures of puwainaphycins A-E, including most of the stereochemical features, have been elucidated by a combination of spectral and chemical methods.