A divergent approach to patchouli sesquiterpenes: Synthesis of 3-oxopatchouli alcohol, 5-oxo-7-hydroxy-13-norcycloseychellene, 6-methoxy-4,12-dehydro-13-norcycloseychellene and patchouli alcohol

Article abstract of DOI:10.1016/S0040-4039(00)97185-5

α′-Methylation of (-)-carvone followed by bicycloannulation with vinyltriphenylphosphonium bromide gives a 59% yield of a tricycio[3.2.1.0^2,7]octan-6-one which can be converted to precursors of (-)-patchouli alcohol, (-)-seychellene and (-)-cyc