Journal of Pharmaceutical Sciences p. 418 - 420 (1984)
Update date:2022-08-17
Topics:
Massil
Guey-Yueh Shi
Klotz
A series of bissalicyclic esters of methylenecitric acid have been prepared and, as a probe of their potential as antisickling agents, tested for their ability to modify hemoglobin. Substantial acylation of hemoglobin was obtained with these dicarboxylate esters at 1-5 mM concentrations.
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