Versatile routes to chiral 4-substituted 2-oxazolindinones and α-amino acids. Use of chiron, [4 + 2] cycloadducts of dialkyl azodi-carboxylates and 2-oxazolones

Article abstract of DOI:10.1248/cpb.40.1077

The thermal reaction of 3-[(1S)-2-alkoxy-1-apocamphanecarbonyl]-2-oxazolones with dialkyl azodicarboxylates results in exclusive formation of [4 + 2] type cycloadducts with moderate levels of diastereofacial selection, which serve as versatile chiral synthons for a wide variety of 4-alkyl and 4-alkyl-2-oxazolidinones as well as α-amino acids.

Full text of DOI:10.1248/cpb.40.1077

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