Five D:C-friedo-oleanane triterpenes from the seeds of Trichosanthes kirilowii MAXIM. and their anti-inflammatory effects

Article abstract of DOI:10.1248/cpb.42.1101

Five triterpenes with a D:C-friedo-oleanane skeleton, D:C-friedo-oleana- 7,9(11)-diene-3β,29-diol (3-epikarounidiol), 7-oxo-D:C-friedo-olean-8-en- 3β-ol (7-oxoisomultiflorenol), 7-oxo-8β-D:C-friedo-olean-9(11)-ene-3α,29- diol, D:C-friedo-olean-8-ene-3α,29-diol (3-epibryonolol), and D:C-friedo- olean-8-ene-3β,29-diol (bryonolol), the first four of which are new naturally occurring compounds, were isolated from the seeds of Trichosanthes kirilowii MAXIM. The structures were determined by spectral and chemical methods. 3-Epikarounidiol, 7-oxoisomultiflorenol, and 3-epibryonolol showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation in mice. The 50% inhibitory dose of these triterpenes for TPA-induced inflammation (1 μg) was 0.2-0.6 mg/ear.

Full text of DOI:10.1248/cpb.42.1101

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NII-Electronic Library Service

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NII-Electronic Library Service

NII-Electronic Library Service