Tetrahedron Letters p. 5783 - 5784 (1994)
Update date:2022-08-11
Topics:
Erukulla, Ravi Kumar
Byun, Hoe-Sup
Bittman, Robert
A high-yielding, 3-step, one-pot conversion of lipid hydroxy acceptors 2 into clinically useful alkylphosphocholines 1 is reported. Reaction of 2 with ethylene chlorophosphite gave phosphite 3, which underwent oxidation and ring opening with bromine in CH2Cl2 to give (2-bromoethyl)phosphate ester 4; hydrolysis of the P-Br bond and quaternization of 4 with aqueous trimethylamine generated 1.
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