Photochemistry of tiaprofenic acid, a nonsteroidal anti-inflammatory drug with phototoxic side effects

DOI: 10.1002/jps.2600810215

Source and publish data:

Journal of Pharmaceutical Sciences p. 181 - 182 (1992)

Update date:2022-08-11

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Authors:

Bosca Bosca

Miranda Miranda

Vargas Vargas

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Article abstract of DOI:10.1002/jps.2600810215

The phototoxic nonsteroidal anti-inflammatory drug tiaprofenic acid (1) is photolabile under aerobic conditions. Irradiation of a methanol solution of 1 under oxygen produces the photoproducts 2, 3, 4, and 5, and also produces a singlet oxygen as evidenced by trapping with 2,5-dimethylfuran.

Full text of DOI:10.1002/jps.2600810215

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