The Synthesis of N-Hydroxy-N'-phenyloctanediamide and Its Inhibitory Effect on Proliferation of AXC Rat Prostate Cancer Cells

Article abstract of DOI:10.1021/jm00008a020

We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid.It provides the product in high yield and purity with a simple purification process.We have found that at 10^-5 M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro.It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.