Convenient chemical synthesis of CMP-N-acetylneuraminate (CMP-Neu-5-Ac)

Article abstract of DOI:10.1016/S0040-4039(00)60773-6

Reaction of sialyl phosphites 1 and 2 with dibenzyl phosphate and phenyl phosphate furnished without addition of a catalyst directly the corresponding sialyl phosphates 3 and 4, respectively, in good yields. Similarly, reaction of 1 with acetylated CMP 5 afforded exclusively β-configurated acetylated CMP-Neu-5-Ac (6); which was readily transformed into natural sialyl donor CMP-Neu-5-Ac (7).