Structurally simplified squalestatins: A convenient route to a 6,7-unsubstituted derivative

DOI: 10.1016/S0040-4039(00)79351-8

Source and publish data:

Tetrahedron Letters p. 4357 - 4360 (1993)

Update date:2022-08-11

Topics:

Authors:

Lester Lester

Gilbin Gilbin

Inglis Inglis

Procopiou

Ross Ross

Watson Watson

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Article abstract of DOI:10.1016/S0040-4039(00)79351-8

The squalestatin 1, has been converted into the 6,7-unsubstituted analogue, 3, via inversion of the alcohol at C7, selective removal of the α,β-unsaturated ester at C6 followed by a Corey-Hopkins deoxygenation of the generated 6R,7S-diol.

Full text of DOI:10.1016/S0040-4039(00)79351-8

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