New chiral oxazaphospholidine oxides as highly efficient catalysts in the enantioselective reduction of ketones

Article abstract of DOI:10.1016/0040-4039(96)01928-4

New catalysts 4-10 for the asymmetric reduction of the two model ketones 13 and 14 by borane are described. These catalysts are easily prepared by reaction of the corresponding β-amino alcohols with phenylphosphonic dichloride or alternatively by oxidatio