A new reagent for solid and solution phase synthesis of protected guanidines from amines

Article abstract of DOI:10.1016/S0040-4039(98)80017-8

A new reagent 4-nitro-1-H-pyrazole-1-[N, N'-bis(tert- butoxycarbonyl)]carboxamidine has been developed to effect the rapid and efficient synthesis of bis(carbamate)-protected guanidines from primary and secondary amines. The reagent is a more electrophili