One-pot Deprotection and Coupling of Peptides by the Fmoc Strategy

DOI: 10.1246/cl.1993.721

Source and publish data:

Chemistry Letters p. 721 - 724 (1993)

Update date:2022-08-11

Topics:

Authors:

Ueki, Masaaki

Nishigaki, Naohiko

Aoki, Hiroko

Tsurusaki, Takeshi

Katoh, Tsuyoshi

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Article abstract of DOI:10.1246/cl.1993.721

9-Fluorenylmethyloxycarbonyl (Fmoc) group can be quickly removed with tetrabutylammonium fluoride hydrate (TBAF*xH2O) in the presence of a large excess of phenylmethanethiol or 1-octanethiol. Subsequent oxidation of the thiol with bis(1-methyl-1H-tetrazol-5-yl) disulfide simultaneously inactivated the TBAF and enabled one-pot peptide bond elongation by the Fmoc strategy.

Full text of DOI:10.1246/cl.1993.721

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