1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites

DOI: 10.1016/0960-894X(96)00036-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 439 - 440 (1996)

Update date:2022-08-17

Topics:

Authors:

Zheng, Hua

Espitia, Stephen A.

Ilyin, Victor

Hawkinson, Jon E.

Woodward, Richard M.

Weber, Eckard

Keana, John F. W.

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Article abstract of DOI:10.1016/0960-894X(96)00036-4

A series of 1-hydroxy-1,4-dihydroquinoxaline-2,3-diones was synthesized and assayed for NMDA receptor glycine site antagonism. Except for 4a, these were found to be 3-80 times weaker antagonists than the analogous 1,4-dihydroquinoxaline-2,3-diones.

Full text of DOI:10.1016/0960-894X(96)00036-4

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