Bioorganic and Medicinal Chemistry Letters p. 439 - 440 (1996)
Update date:2022-08-17
Topics:
Zheng, Hua
Espitia, Stephen A.
Ilyin, Victor
Hawkinson, Jon E.
Woodward, Richard M.
Weber, Eckard
Keana, John F. W.
A series of 1-hydroxy-1,4-dihydroquinoxaline-2,3-diones was synthesized and assayed for NMDA receptor glycine site antagonism. Except for 4a, these were found to be 3-80 times weaker antagonists than the analogous 1,4-dihydroquinoxaline-2,3-diones.
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