Directed metalation/ligand coupling approach to the enantioselective synthesis of 1,1'-binaphthyls

Article abstract of DOI:10.1016/S0957-4166(00)82215-6

Introduction of a 2-isopropoxycarbonyl or 2-N,N-dimethylcarbamoyl group into homochiral 1-p-tolyl- or 1-t-butyl-sulfinylnaphthalenes, via directed metalation reaction, followed by ligand coupling reaction with 1-naphthylmagnesium bromide, furnished atropisomeric 1,1'-binaphthyls in 82-95% enantiomeric excess (e.e.).