Highly Stereoselective Synthesis of cis-(2R,3S)-3-Hydroxyproline

DOI: 10.1016/S0040-4039(00)61611-8

Source and publish data:

Tetrahedron Letters p. 7107 - 7110 (1993)

Update date:2022-08-03

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Authors:

Jurczak, Janusz

Prokopowicz, Piotr

Golebiowski, Adam

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Article abstract of DOI:10.1016/S0040-4039(00)61611-8

Allyltrimethylsilane (5) reacted with N-carbobenzoxy-O-tert-butyldimethylsilyl-L-serinal (4) to give with high diastereoselectivity syn-adduct 3 which was subsequently transformed into cis-(2R,3S)-3-hydroxyproline (1).

Full text of DOI:10.1016/S0040-4039(00)61611-8

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