Tetrahedron p. 3261 - 3272 (1996)
Update date:2022-08-10
Topics:
Brzezinski, Jacek Z.
Bzowski, Henryk B.
Epsztajn, Jan
The synthesis of pyridopyridazinones 7 and 8 via the reaction of hydroxyazaisoindolinones 5 and 6 with hydrazine hydrate is described. Compounds 7 and 8 were then subjected to reactions with alkyl halides to furnish N-alkyl derivatives. Only in the reaction of pyridopyridazinone 8 with benzyl bromide was the O-benzylpyridopyridazine 14b formed in addition to the N-benzylpyridopyridazinone 14a.
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Doi:10.1039/jr9370001305
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(2003)
