Synthesis of (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives from (S)-aspartic acid

DOI: 10.1016/0022-1139(93)02907-V

Source and publish data:

Journal of Fluorine Chemistry p. 87 - 90 (1994)

Update date:2022-08-11

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Authors:

Burger, Klaus

Rudolph, Martin

Fehn, Susanna

Sewald, Norbert

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Article abstract of DOI:10.1016/0022-1139(93)02907-V

Syntheses for (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives are described starting from (S)-aspartic acid, using hexafluoroacetone as the protecting reagent and DAST as the fluorinating agent.

Full text of DOI:10.1016/0022-1139(93)02907-V

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